Canto Ostinato is the best-known piece by the Dutch composer Simeon Ten Holt (1923-2012) and has already become an icon of minimalist music. A performance of Canto Ostinato is more of a ritual than a concert – the first performance lasted two hours – in which the listener becomes a witness (just a piece) of an eternal process. A process that seems to have begun a long time before the preview of the concert, and that will continue beyond the end. Canto Ostinato then makes audible a piece of infinity. Because time here becomes the space in which musical objects float, and repetition aims to create situations in which these objects become transparent. Through Canto Ostinato we will explore neurophysical characteristics of our brain related to repetition, trance and pleasure, identifying dopaminergic, limbic and paralimbic mechanisms and their associated cortical loops.